AMY1C

Protein-coding gene in the species Homo sapiens
AMY1C
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

1C8Q, 1JXJ, 1JXK, 1MFU, 1MFV, 1NM9, 1Q4N, 1SMD, 1XV8, 1Z32, 3BLK, 3BLP, 3DHP

Identifiers
AliasesAMY1C, AMY1, amylase, alpha 1C (salivary), amylase alpha 1C (salivary), amylase alpha 1C
External IDsOMIM: 104702; HomoloGene: 133998; GeneCards: AMY1C; OMA:AMY1C - orthologs
EC number3.2.1.1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for AMY1C
Genomic location for AMY1C
Band1p21.1Start103,745,323 bp[1]
End103,758,726 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • testicle

  • olfactory zone of nasal mucosa

  • gonad

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • body of pancreas

  • right lung

  • upper lobe of left lung

  • left testis
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • alpha-amylase activity
  • hydrolase activity
  • catalytic activity
  • metal ion binding
  • hydrolase activity, acting on glycosyl bonds
  • cation binding
Cellular component
  • extracellular region
  • extracellular exosome
  • extracellular space
Biological process
  • digestion
  • metabolism
  • carbohydrate metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

278

n/a

Ensembl

ENSG00000187733

n/a

UniProt

P04745

n/a

RefSeq (mRNA)

NM_001008219
NM_001346780

n/a

RefSeq (protein)

NP_001008220
NP_001333709
NP_001008222
NP_004029
NP_001008219

n/a

Location (UCSC)Chr 1: 103.75 – 103.76 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

The human AMY1C gene encodes the protein Amylase, alpha 1C (salivary). [3]

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either the salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland.[4] See also Amylase § Evolution.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187733 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: Amylase, alpha 1C (salivary)". Retrieved 2013-02-14.
  4. ^ [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## Transcript_exon_combination_evidence :: AK313275.1 [ECO:0000332] ##RefSeq-Attributes-END##

External links

  • Overview of all the structural information available in the PDB for UniProt: P04745 (Human Alpha-amylase 1) at the PDBe-KB.

Further reading


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