ALDH3B2

Protein-coding gene in the species Homo sapiens

ALDH3B2

Identifiers

Aliases

ALDH3B2, ALDH8, aldehyde dehydrogenase 3 family member B2

External IDs

OMIM: 601917; MGI: 1920708; GeneCards: ALDH3B2; OMA:ALDH3B2 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.2	Start	67,662,155 bp^[1]
Band	11q13.2	End	67,681,224 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	4,008,645 bp^[2]
Band	19\|19 A	End	4,022,103 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of thigh

skin of arm

vulva

skin of abdomen

gingival epithelium

oral cavity

parotid gland

human penis

nipple

skin of hip

Top expressed in

granulocyte

lumbar subsegment of spinal cord

proximal tubule

right kidney

outer nuclear layer

skin of back

skin of external ear

morula

blastocyst

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	3-chloroallyl aldehyde dehydrogenase activity oxidoreductase activity aldehyde dehydrogenase [NAD(P)+ activity] oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Cellular component	lipid droplet
Biological process	ethanol catabolic process metabolism alcohol metabolic process lipid metabolism sphingolipid biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


222


73458

Ensembl


ENSG00000132746


ENSMUSG00000037263

UniProt


P48448


J3QMK6

RefSeq (mRNA)

NM_000695 NM_001031615 NM_001354345 NM_001393400 NM_001393401
NM_001393402


NM_028545

RefSeq (protein)


NP_000686 NP_001026786 NP_001341274


NP_082821

Location (UCSC)

Chr 11: 67.66 – 67.68 Mb

Chr 19: 4.01 – 4.02 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Aldehyde dehydrogenase family 3 member B2 is an enzyme that in humans is encoded by the ALDH3B2 gene.^[5]^[6]^[7]

This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132746 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037263 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hsu LC, Chang WC (Dec 1996). "Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family". Gene. 174 (2): 319–22. doi:10.1016/0378-1119(96)00087-X. PMID 8890755.
^ Hsu LC, Chang WC, Yoshida A (Jun 1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene. 189 (1): 89–94. doi:10.1016/S0378-1119(96)00839-6. PMID 9161417.
^ ^a ^b "Entrez Gene: ALDH3B2 aldehyde dehydrogenase 3 family, member B2".

External links

Human ALDH3B2 genome location and ALDH3B2 gene details page in the UCSC Genome Browser.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Hsu LC, Chang WC, Lin SW, Yoshida A (1995). "Cloning and Characterization of Genes Encoding Four Additional Human Aldehyde Dehydrogenase Isozymes". Enzymology and Molecular Biology of Carbonyl Metabolism 5. Advances in Experimental Medicine and Biology. Vol. 372. pp. 159–68. doi:10.1007/978-1-4615-1965-2_21. ISBN 978-1-4613-5808-4. PMID 7484374.