ACER3

Protein-coding gene in the species Homo sapiens
ACER3
Identifiers
AliasesACER3, APHC, PHCA, alkaline ceramidase 3, PLDECO
External IDsOMIM: 617036 MGI: 1913440 HomoloGene: 5410 GeneCards: ACER3
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ACER3
Genomic location for ACER3
Band11q13.5Start76,860,859 bp[1]
End77,026,797 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ACER3
Genomic location for ACER3
Band7|7 E1Start98,206,389 bp[2]
End98,321,208 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • inferior ganglion of vagus nerve

  • corpus callosum

  • pancreatic epithelial cell

  • Brodmann area 46

  • subthalamic nucleus

  • pons

  • medulla oblongata

  • trigeminal ganglion

  • superior vestibular nucleus
Top expressed in
  • conjunctival fornix

  • cornea

  • interventricular septum

  • hair follicle

  • sciatic nerve

  • skin of back

  • skin of abdomen

  • epithelium of stomach

  • right lung

  • otolith organ
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
  • hydrolase activity
  • phytoceramidase activity
  • N-acylsphingosine amidohydrolase activity
  • dihydroceramidase activity
  • ceramidase activity
  • calcium ion binding
  • zinc ion binding
  • metal ion binding
Cellular component
  • integral component of membrane
  • integral component of Golgi membrane
  • integral component of endoplasmic reticulum membrane
  • Golgi membrane
  • Golgi apparatus
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • membrane
Biological process
  • sphingosine biosynthetic process
  • sphingolipid biosynthetic process
  • phytosphingosine biosynthetic process
  • ceramide metabolic process
  • positive regulation of cell population proliferation
  • inflammatory response
  • myelination
  • regulation of programmed cell death
  • ceramide catabolic process
  • lipid metabolism
  • sphingolipid metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55331

66190

Ensembl

ENSG00000078124

ENSMUSG00000030760

UniProt

Q9NUN7

Q9D099

RefSeq (mRNA)

NM_001300953
NM_001300954
NM_001300955
NM_018367

NM_025408

RefSeq (protein)

NP_001287882
NP_001287883
NP_001287884
NP_060837

NP_079684
NP_001347544
NP_001347545
NP_001347546

Location (UCSC)Chr 11: 76.86 – 77.03 MbChr 7: 98.21 – 98.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078124 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030760 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (July 2001). "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. Chem. 276 (28): 26577–88. doi:10.1074/jbc.M102818200. PMID 11356846.
  6. ^ Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.

External links

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Wheeler HE, Metter EJ, Tanaka T, et al. (2009). Gibson G (ed.). "Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging". PLOS Genet. 5 (10): e1000685. doi:10.1371/journal.pgen.1000685. PMC 2752811. PMID 19834535.
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